Alisma Orientalis Extract 4:1 TLC
Alisma extracts of alisma plants (Alismaplan-tago-aquaticaL.var.orientaleSamuels) of alisma tuber extracts. It mainly contains tritterpene compound Alismatil alcohol A, alismatil alcohol B, volatile oil, alkaloid and other components, which has the effect of relieving urine Chemicalbook and clearing damp heat. It is clinically used for the treatment of adverse urination, water swelling, diarrhea and little urine, phlegm drink vertigo, heat dlesome pain, high blood fat and other diseases. Its extract is the carrier of various advanced technologies of modern Chinese medicine and the main raw material of Chinese medicine preparation. It has less toxic and side effects and is not easy to produce drug resistance, which has incomparable advantages in this aspect.
Pharmacological action
1. Hypolipidemic effect Alisma orientalis extract, alcohol extract and alcohol infusion, etc., have preventive and therapeutic effects on experimental hyperlipidemia in rabbits. It can prevent and inhibit the formation of total experimental aortic atherosclerotic plaques and ease its development. Alisma can significantly reduce various lipids in the aorta, especially cholesterol, which leads to aortic plaque reduction. Intraperitoneal injection of the fat-soluble part of Alisma orientalis has the effect of clarifying plasma lipids in rats with hyperlipidemia induced by oral administration of cottonseed oil; it has obvious cholesterol-lowering and anti-atherogenic effects on experimental animal hypercholesterolemia hardening effect. Its active ingredients are alisol A and the acetates of A, B, and C, especially the alisol A acetate has the strongest effect. Alisitol A can inhibit the absorption of cholesterol in the small intestine of rats and the ability to esterify cholesterol in the small intestine of mice.
2. Liver protection and anti-fatty liver effects Alisma orientalis extract can reduce the fat content in the liver of rabbits fed with cholesterol and high fat. The choline, lecithin, amino acids and benzene-acetone soluble part T contained in the extract all have It has anti-fatty liver effect, has a protective effect on acute liver injury caused by carbon tetrachloride, can inhibit the accumulation of fat in the liver, inhibit the decline of phospholipids in plasma and liver, and improve liver pigment excretion function. Alisma can significantly reduce the contents of total cholesterol, cholesterol esters, triglycerides and total esters in the liver of experimental high-fat animal models. Alisma can reduce the Lee index uterus and testis surrounding fat index and serum triglyceride content in experimentally obese rats, and its mechanism of action may be caused by affecting enzymes related to cholesterol metabolism and inhibiting intrahepatic triglyceride synthesis.
3. Diuretic effect Alisma diuresis extract has diuretic effect on humans and animals, which can increase the excretion of sodium, chloride, potassium and urea in the urine. Intraperitoneal injection of Alisma elata extract can reduce the retention of urea and cholesterol in blood of rabbits with nephritis caused by nitroglycerin. The potassium content in Alisma is as high as 147.5 mg%, which can significantly increase the urinary potassium excretion in adrenalectomy rats. The ethanolic extract of Alisma orientalis has a dose-dependent inhibition of renal Na+, K+-ATPase activity.
4. The effect on cardiovascular system Alisma extract is intravenously injected to dogs or rabbits, which has a mild antihypertensive effect. In vitro, there is a slow relaxation effect on epinephrine-induced contraction of isolated rabbit aortic strips. Alisma alcohol extract can significantly expand coronary artery in isolated rabbit heart, has no antagonistic effect on myocardial ischemia caused by vasopressin, and has a slight inhibitory effect on myocardial contractility. Oral or intraperitoneal administration of Alisitol has a durable and moderate-intensity antihypertensive effect on DocA hypertension, renal hypertension and essential hypertension rat models. Alisma has a significant inhibitory effect on platelet aggregation, and its use with hawthorn can significantly enhance its inhibitory effect on platelet aggregation.
5. Effects on the immune system Alisma orientalis decoction can significantly inhibit the clearance rate of carbon particles in mice and contact dermatitis caused by DNCB, but has no significant effect on the content of IgG in mice and delayed footpad swelling in mice caused by SRBC. Alisma extract from Alisma has a selective effect on the aggregation of human erythrocytes, mouse spleen lymphocytes and the inhibition of macrophage migration. Both human and guinea pig erythrocytes can be aggregated by Alisma, and it has no blood type specificity. The spleen lymphocyte aggregation in mice was similar to that of ConA, but slightly stronger than that of PHA.
6. Anti-inflammatory effect Alisma decoction can significantly reduce the swelling of mouse auricle caused by xylene, inhibit the proliferation of rat cotton ball granulation tissue, but has no significant effect on serum antibody content and rat adrenal ascorbic acid content.
7. The ability to scavenge free radicals The research shows that Alisma n-butanol extract, ethyl acetate extract and water extract have strong scavenging ability to free radicals.
8. Anti-nephrolithiasis The methanol hot extract of Alisma 200mg/kg per day for immune complex (IC) nephritis rats for 20 days can inhibit urinary protein excretion, inhibit glomerular cell infiltration and renal tubular degeneration And regeneration, inhibit the occurrence of various complications in IC nephritis rats, indicating that Alisma has significant anti-nephritis activity.
9. Other effects Alisma orientalis extract has a mild hypoglycemic effect when injected subcutaneously into rabbits. Alisma decoction has an antagonistic effect on the spasm of rabbit muscle caused by acetylcholine, can moderately increase the coronary flow in rabbits and relax the isolated rabbit thoracic aortic smooth muscle, and has a slight inhibitory effect on myocardial contractility.